doripenem indications/contra

Stem definitionDrug idCAS RN
analogues of penicillanic acid antibiotics modified in the five-membered ring 4149 148016-81-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doribax
  • doripenem
  • doripenem hydrate
has antibacterial activity; structure given in first source
  • Molecular weight: 420.50
  • Formula: C15H24N4O6S2
  • CLOGP: -3.83
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 162.06
  • ALOGS: -2.13
  • ROTB: 6

Drug dosage:

DoseUnitRoute
1.50 g P

Approvals:

DateAgencyCompanyOrphan
Oct. 12, 2007 FDA SHIONOGI INC

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC J01DH04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Carbapenems
FDA Chemical/Ingredient N0000011294 Carbapenems
FDA EPC N0000175496 Penem Antibacterial

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Pyelonephritis indication 45816000 DOID:11400
Abdominal abscess indication 75100008
Cholecystitis indication 76581006 DOID:1949
Infectious disease of abdomen indication 128070006
Complicated appendicitis indication 418171008
Complicated Urinary Tract Infections indication
Impaired renal function disorder contraindication 197663003
Pseudomembranous enterocolitis contraindication 397683000 DOID:0060185

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.79 acidic
pKa2 8.53 acidic
pKa3 11.22 acidic
pKa4 9.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
C1967545 UMLSCUI
D01836 KEGG_DRUG
119771 RXNORM
24610 MMSL
d07049 MMSL
4026738 VANDF
428352004 SNOMEDCT_US
429369006 SNOMEDCT_US
N0000179506 NDFRT
N0000176120 NDFRT
012366 NDDF
246877 MMSL
CHEMBL491571 ChEMBL_ID
CHEMBL1276416 ChEMBL_ID
BHV525JOBH UNII
7975 INN_ID
DB06211 DRUGBANK_ID
73303 PUBCHEM_CID
C099245 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135928 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Doribax HUMAN PRESCRIPTION DRUG LABEL 1 59630-309 POWDER, FOR SOLUTION 250 mg INTRAVENOUS NDA 17 sections
Doribax HUMAN PRESCRIPTION DRUG LABEL 1 59630-320 POWDER, FOR SOLUTION 500 mg INTRAVENOUS NDA 17 sections
DORIPENEM HUMAN PRESCRIPTION DRUG LABEL 1 60505-6160 POWDER, FOR SOLUTION 250 mg INTRAVENOUS NDA 17 sections
DORIPENEM HUMAN PRESCRIPTION DRUG LABEL 1 60505-6161 POWDER, FOR SOLUTION 500 mg INTRAVENOUS NDA 17 sections