zimeldine indications/contra

Stem definitionDrug idCAS RN
2863 56775-88-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zimeldine hydrochloride hydrate
  • zimeldine
  • zimelidine
  • cis-Zimelidine
  • zimelidine dihydrochloride monohydrate
  • zimelidine dihydrochloride hydrate
  • zimelidine dihydrochloride
  • zimelidine hydrochloride
  • zimelidine HCl
One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)
  • Molecular weight: 317.23
  • Formula: C16H17BrN2
  • CLOGP: 3.19
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 16.13
  • ALOGS: -4.12
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.20 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N06AB02 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.67 Basic
pKa2 2.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter Ki 6.82 PDSP
D(2) dopamine receptor GPCR Ki 5.73 PDSP
Sodium-dependent noradrenaline transporter Transporter Ki 5.03 PDSP

External reference:

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IDSource
D06367 KEGG_DRUG
3J928617DW UNII
4067 INN_ID
CHEMBL37744 ChEMBL_ID
N0000167235 NDFRT
96201004 SNOMEDCT_US
5365247 PUBCHEM_CID
CHEMBL1257002 ChEMBL_ID
CHEMBL1257115 ChEMBL_ID
DB04832 DRUGBANK_ID
D015031 MESH_DESCRIPTOR_UI
CHEBI:135357 CHEBI

Pharmaceutical products:

None