hydroxystilbamidine indications/contra

Stem definitionDrug idCAS RN
1398 495-99-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydroxystilbamidine isethionate
  • hydroxystilbamidine
  • hydroxystilbamidine isetionate
  • hydroxystilbamidine hydrochloride
minor descriptor (63-86); on-line & INDEX MEDICUS search STILBAMIDINES (66-86); RN given refers to parent cpd
  • Molecular weight: 280.33
  • Formula: C16H16N4O
  • CLOGP: 1.28
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 5
  • TPSA: 119.97
  • ALOGS: -3.64
  • ROTB: 4

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 22, 1953 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.27 acidic
pKa2 9.77 Basic
pKa3 9.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Trypsin Unclassified AC50 5.50 CHEMBL

External reference:

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IDSource
0163PVD2QZ UNII
533-22-2 SECONDARY_CAS_RN
456 INN_ID
DB01040 DRUGBANK_ID
16051925 PUBCHEM_CID
004967 NDDF
CHEMBL1301 ChEMBL_ID
CHEBI:135161 CHEBI
CHEMBL1200847 ChEMBL_ID
C100274 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None